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It can be hard to imagine another famous actor or actress in a popular movie. Because not all filmmakers get their first choices during casting, there are a number of examples where a different star could have played a memorable character if they had been available or said yes.

Julia RobertsGwyneth PaltrowChristina ApplegateReese WitherspoonEmily BluntScarlett JohanssonBilly CrystalJennifer HudsonGabourey SidibeWill Smith